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What is Profhilo

PROFHILO® is manufactured by IBSA Farmaceutici Italia in a U.S. FDA approved site in Italy. A unique stabilised injectable hyaluronic acid for treating skin laxity. 

BDDE-free and with one of the highest concentrations of HA on the market (64 mg / 2 ml), it is not only boosting and hydrating the skin, but also remodels the ageing and sagging tissue.

Profhilo delivers great results as a treatment on its own or in combination with other aesthetics treatments currently on offer.

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How Does Profhilo Works

As a stabilised product Profhilo lasts in the skin around 28 days. During this time the stimulation of 4 different types of collagen and elastin takes place by slow release of HA.The stimulation results in significant tissue improvement. Therefore we cannot say that Profhilo is a skin booster as it also has a significant tightening / lifting effect on the tissue.

Unique Product

There are many characteristics that make Profhilo unique from anything else available on the market right now. There is no BDDE content. It is thermally cross-linked generating stabilised hybrid co-operative complexes of H-HA and L-HA. Despite its high HA content, it has a low inflammatory profile coupled with pro-healing properties backed by clinical studies. To fully understand this new concept in anti-ageing medicine we have to take a look at the technology first.


In Profhilo, L-HA is released slowly from the HA hybrid complexes and therefore does not trigger the first inflammatory cytokines making it very biocompatible. It also increas¬es patient comfort during and after treatment and provides hydration to the skin especially in the epidermis - the Hydro effect.

H-HA in Profhilo provides a stable HA architecture in the dermis. This gives a volumetric effect - the Lift effect.

Another advantage of the stable co-operative hybrid complex when compared to H-HA and L-HA is the increase in the ex¬pression levels of type I and type III collagen in fibroblast and type IV and VII collagen in keratinocytes.

This results in improved skin quality and skin hydration both in the dermis and epidermis. There is also increased production of endogenous HA and elastin giving the skin a more youthful look.

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To maximise the diffusion in the malar and sub-malar areas:

• The BAP were specifically chosen in anatomically respective areas
• The dilution phenomenon of the product itself
• 5 injections per side
• Reduced pain (slow injection)
• Lower possibility of bruising or hematoma
• Reduced number of treatment sessions
• Greater patient compliance

Profhilo Results

Profhilo provides deep-down, long-lasting hydration and smoother, tighter skin. It is recommend having a top up treatment after 6-12 months to maintain results.

The patient should notice an improved skin tone, texture, elasticity and firmness with increased hydration and radiance. The result is healthier, softer and smoother skin.


 Aftercare for Profhilo is similar to that of other injectable treatments. The patient can use a cold pack to reduce any redness or swelling and keep hydrated to ensure you get the best results from treatment.

However, it is important for the patient to also know the following:

  • Avoid applying make-up to the treated area for 24 hours

  • Avoid physical activity for 24 hours

  • Avoid other cosmetic, beauty or dental treatments for at least a week

  • Use a high SPF sun-protection after treatment

  • Avoid extremes of hot or cold

  • Massage is not required, the product with diffuse naturally without any intervention

  • Contact the clinic as soon as possible if you have any concerns


Profhilo’s low inflammatory profile, coupled with its clinically proven pro-healing properties means it is very safe and requires minimal downtime.

It is a very similar downtime to receiving anti-ageing injections, for example there may be some residual redness and swelling at the injection sites, however, this tends to settle very quickly with the vast majority of clients, and it is possible it will be noticeable by the time you leave the clinic. However, some clients who are prone to bleeding and bruising or who have sensitive skin may have some noticeable redness and perhaps a little bruising which appears a day or so later. Sometimes, a small lump is visible or palpated at the injection site where the product has been placed, however, this usually dissipates over 24 hours as it is absorbed into the skin.

Where can Profhilo® be used?

Profhilo is generally administered onto five key injection sites on the face:

  • The tops of your cheeks

  • The sides of your face

  • The lines around your mouth

  • Your nasolabial folds

  • Your laughter lines

Additionally, if necessary, it can also be used to treat other parts of your body besides your face, including injection points in your:

  • Hands

  • Upper arms

  • Neck

  • Chest

  • Décolletage

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